Search results for "Biocompatible polymer"
showing 7 items of 7 documents
Biocompatible Polymers and Processing Techniques in Drug Delivery and Tissue Engineering
2013
PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions
2015
Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-polylactic acid (PHEA-PLA), purposely synthesized to be used in the controlled release of active molecules poorly soluble in water. To this aim an amphiphilic derivative of PHEA, a hydrophilic polymer, was synthesized by derivatization of the polymeric backbone with hydrophobic grafts of polylactic acid (PLA). The achieved copolymer was thus used to produce nanoparticles loaded with α toc…
SYNTHESIS AND CHARACTERIZATION OF NEW AMPHIPHILIC COPOLYMERS BASED ON A POLY(HYDROXYETHYL)-D,L-ASPARTAMIDE (PHEA) FOR THE COATING OF GOLD NANOPARTICL…
2012
Hemoglobin loaded polymeric nanoparticles: preparation and characterizations.
2011
In the present work polymeric nanoparticles based on Poly (maleic anhydride-alt-butyl vinyl ether) 5% grafted with m-PEG (2000) and 95% grafted with 2-methoxyethanol (VAM41-PEG) were loaded with human hemoglobin (Hb) and characterized from a physicochemical point of view. The assessment of structural and functional features of the loaded Hb was performed and the effect of the introduction of different reducing agents as aimed at minimizing Hb oxidation during the nanoparticles formulation process, was also investigated. Nanoparticles possessing an average diameter of 138 ± 10 nm and physicochemical features suitable for this kind of application were successfully obtained. Although the oxida…
Biomaterials for Biotechnological and Pharmaceutical application
2010
SCAFFOLDS POLILATTIDICI PER APPLICAZIONI BIOMEDICHE
2010
Aminofunctional polyethers: smart materials for applications in solution and on surfaces
2013
In recent years, biocompatible polyethers with multi-aminofunctionality have been used for a variety of applications in different fields. Both established and recently developed synthesis strategies for such polymers and applications as stimuli-responsive materials, non-viral vectors, shell crosslinked micelles and for surface functionalization are reviewed. The intriguing potential of such materials is due to both polyether and polyamine components and can thus be readily tuned by the copolymer microstructure and composition. © 2013 Society of Chemical Industry